Published by Florence CULTIER
On Oct 27, 2020 9:15:20 AM

Lactoferrin, a key ingredient in infant formulas

Lactoferrin is a protein found naturally in breast milk. The WHO recommends mothers exclusively breastfeed infants for the first six months of life. However, for various reasons, breastfeeding for this length of time is not always simple. For this reason, there are different types of infant formulas whose compositions vary with the age and needs of infants. Given the benefits babies reap from lactoferrin, infant formulas are increasingly fortified with this protein.

What is an infant formula ? 

The WHO recommends feeding an infant breast milk exclusively during the first six months of their life. From six months to two years or older, it recommends giving other suitable sources of nutrition alongside breast milk to ensure optimum growth and development. However, depending on what parents choose, infant formulas can be fed to babies as a substitute or as a gradual bridge given with breast milk. The objective in producing infant formulas is to create a product with a composition as close as possible to that of breast milk.

Infant formulas are generally made from cow’s milk. Technological processes allow manufacturers to tailor the nutrient composition to make it as similar as possible to that of breast milk. Macronutrient compositions are adjusted in the process. For example, protein content changes from 35 g to 12-17 g. Formulas are fortified with micronutrients, which are vitamins and minerals. Some manufacturers have been known to add probiotics, fibres and other nutrients to enrich their formulas. Once the final formula is ready, it is concentrated, then dehydrated to obtain a ready-to-use powder. This final drying stage improves the storage life of the product. Infant formula production is subject to extremely stringent regulations.

The various formulas according to age

Infant formulas adapted to baby's needs

Paediatricians can advise parents on the various infant formula options according to their baby’s age and needs:

      • “Infant formulas” or “infant milks” (those made only from cow’s or goat’s milk proteins), also called “1st age milks”, can be used from birth until suitable supplemental foods are introduced. The goal is to fully meet the nutritional needs of newborns. 
      • Once suitable supplemental foods have been introduced, baby can be given “follow-on formulas” or “follow-on milks” (those made only from cow’s or goat’s milk proteins), also called “2nd age milks”. (In accordance with current EU legislation). This is when babies begin to diversify the foods they eat, generally between 6 - 12 months. Its composition meets the nutritional needs of healthy infants.
  • And finally, the “growing-up milk” can be used alongside the 2nd age milk for toddlers aged one to three. It is fortified in vitamins, iron and essential fatty acids to prevent deficiencies and to promote neurological development. This is because cow’s milk is missing some of the vitamins, iron and essential fatty acids baby needs. Keep in mind that growing-up milk is considered a foodstuff and not an infant formula. Therefore, it is not subject to the same regulatory obligations as infant formula. 
    Bébé fille et biberon

The benefits of lactoferrin

Lactoferrin is a glycoprotein found in high concentrations in breast milk, weighing in at number three among the major proteins. It acts as an antimicrobial agent by binding to the iron, thus preventing pathogenic bacteria from using it to develop. That’s why hospitals use lactoferrin to help reduce infections in preterm infants. 

It has also been proven that lactoferrin boosts the activity of leukocytes, or white blood cells, which is our body’s natural defence against infections. Moreover, it enhances gut immune response. 

As an internal mediator, this protein displays immunomodulatory activities that contribute to the maintenance of immune homoeostasis.

In addition to its ability to help the body ward off attacks, lactoferrin acts as an immunomodulating anti-inflammatory.

Why is it beneficial to infants ? 

At birth, an infant’s immune system functions properly, but it has not yet had to fight off pathogens, and therefore lacks any immunological memory. Lactoferrin helps the newborn’s immune system develop properly by activating natural defences in the small intestine, an extremely fragile organ in the first months of infant life. Infants therefore need lactoferrin because it stimulates the natural defences in order to ‘train’ the newborn’s body to fight off attacks.

The benefits of lactoferrin are clear: it promotes the maturation of the digestive system and acts as a defence against infection, notably in preterm infants. (Ref.): M.Pammi, G. Suresh, Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitisin preterm infants, in: The Cochrane Library, John Wiley Sons, Ltd, 2017.)

Moreover, a study conducted by Chen et al. showed that infants from 4 - 6 months of age that have been given a lactoferrin-enhanced formula are less susceptible to anaemias and other iron deficiencies, and are also less affected by respiratory illnesses. (Ref.: Chen Ke, Zhang Lan, Li Hua, Zhang Ying, Xie Humina, Shang Jia, Tian Weizheng, Yang Ping, Chai Lingying, Mao Meng, Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula, Nutrition. 31 (2015) 304–309.)

It is partly thanks to lactoferrin’s properties that the WHO recommends feeding infants breast milk exclusively until 6 months of age.

This remarkable protein provides a high functional value to infant formulas due to the physiological impact it has on the global health of young children.


Barrington K et al, TheLacunaTrial:adouble-blindrandomizedcontrolledpilot trial oflactoferrinsupplementationin theverypreterminfant, JPerinatol. 2016Aug;36(8):666-9.

Chen K et al,Effectof bovinlactoferrinfromiron-fortifiedformulas ondiarrheaandrespiratorytract infections ofweanedinfants in arandomizedcontrolledtrial, Nutrition. 2016Feb;32(2):222-7

LauterbachR et al.,Lactoferrin- aglycoproteinofgreattherapeuticpotentials, DevPeriodMed. 2016 Apr-Jun;20(2):118-25.

Wang B et al,MolecularDeterminantsof MilkLactoferrinasaBioactive Compound inEarlyNeurodevelopmentandCognition.JPediatr. 2016Jun;173 Suppl:S29-3

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Florence CULTIER

About the author Florence CULTIER

Nutritionniste et ingénieure-maître en Santé, Florence est consultante marketing, spécialiste des marchés de la santé, de l’alimentation et du sport. Elle a fondé l’agence de conseil PepsWork, qui vitamine les projets d’innovation de ses clients, de l’idée jusqu’à la mise en marché, et plus encore.. Florence soutient Armor Protéines sur du content marketing, de la communication scientifique, technique et nutritionnelle, des livres blancs et des articles de blog.